In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction
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- 13 May 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 107 (18) , 2290-2293
- https://doi.org/10.1161/01.cir.0000070931.62772.4e
Abstract
Background— We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model. Methods and Results— Adult farm pigs (n=5) were subjected to closed-chest experimental MI. MR-MSCs (2.8 to 16×107 cells) were injected intramyocardially under x-ray fluoroscopy. MRIs were obtained on a 1.5T MR scanner to demonstrate the location of the MR-MSCs and were correlated with histology. Contrast-enhanced MRI demonstrated successful injection in the infarct and serial MSC tracking was demonstrated in two animals. Conclusion— MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.Keywords
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