Evidence for an Association between the SRD5A2 (Type II Steroid 5α‐Reductase) Locus and Prostate Cancer in Italian Patients
Open Access
- 1 January 2000
- journal article
- research article
- Published by Wiley in Disease Markers
- Vol. 16 (3-4) , 147-150
- https://doi.org/10.1155/2000/683607
Abstract
We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus.Keywords
Funding Information
- National Institutes of Health (CA68581)
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