Biochemical mechanism of action of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
- 31 August 1989
- journal article
- review article
- Published by Elsevier in Toxicology Letters
- Vol. 48 (2) , 121-149
- https://doi.org/10.1016/0378-4274(89)90168-9
Abstract
No abstract availableKeywords
This publication has 100 references indexed in Scilit:
- Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidasePublished by Elsevier ,2004
- Interactions of the 1-methyl-4-phenyl-2, 3-dihydropyridinium species with synthetic dopamine-melaninLife Sciences, 1986
- Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion(MPP+): Reductive activation by NADPH cytochrome P-450 reductaseBiochemical and Biophysical Research Communications, 1986
- The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metalsBiochemical and Biophysical Research Communications, 1985
- IV. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effectsLife Sciences, 1985
- II. Selective accumulation of MPP+ in the substantia nigra: A key to neurotoxicity?Life Sciences, 1985
- I. MPTP neurotoxicity: An overview and characterization of phases of toxicityLife Sciences, 1985
- V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)Life Sciences, 1985
- Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparationsBiochemical and Biophysical Research Communications, 1984
- Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTPBiochemical and Biophysical Research Communications, 1984