Experimental Obstructive Jaundice. Effect on Fibrinogen and Coagulation of the Blood

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Abstract
Fibrinogen content of plasma is not decreased but actually increased in acute experimental obstructive jaundice, probably due to irritative effect of bile on liver. Coagulation time remained above normal limits, but did not parallel the fibrinogen content of the plasma. Coagulation time is not a satisfactory index of a hemorrhagic tendency in the presence of jaundice. Diminution of fibrinogen content does not parallel the degree of liver destruction. The Wu method for determination of fibrinogen is not satisfactory when exact quantitative analysis of blood proteins is done. The Tyrosine equivalent for dogs was found to vary from 12.5 to 19.7. This was learned after determinations were made from 24 samples of blood. For comparative analysis as herein used, the Wu method serves the desired purpose.

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