Experimental Gastric and Duodenal Ulcer.

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Abstract
Daily intramusc. admn. to rabbits of 30 mg. of histamine and 1 mg. of nitroglycerine, embedded in a mixture of beeswax and mineral oil, was carried on until death of the animal or until a total of 14 daily injns. Acute, necrotic, perforating lesions of the stomach or duodenum were produced in approx. 30% of the animals. These lesions were fundamentally different from typical human peptic ulcers. Bilateral subdia-phragmatic vagotomy did not produce gastric or duodenal ulcerations within 47 days in rabbits maintained on a diet of Purine rabbit pellets, carrots and water. Chronic histamine and nitroglycerine stimulation did not produce gastric or duodenal ulcerative lesions in vagotomised rabbits within a period of 16 days. Apparently, gastric and duodenal lesions produced in rabbits by chronic histamine and nitroglycerine stimulation are not suitable for exptl. assessment of ulcer-prevention measures.

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