A comparative crossover study of two long-acting bronchodilator preparations

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Abstract
A comparative crossover investigation was carried out in 18 patients with reversible airways obstruction to assess the bronchodilator effectiveness of aminophylline and salbutamol in long-acting tablet form. Patients received treatment for 4 weeks with either salbutamol 8 mg tablets in a dose of 2 tablets b.d. or aminophylline 225 mg tablets in a dose of 1 tablet b.d. increasing to 2 tablets b.d. after 1 week. They were then crossed over to the alternative preparation for a further 4 weeks. Peak expiratory flow rates (PEF) were measured at weekly intervals. Results showed that the aminophylline tablets produced a highly significant (p < 0.002) improvement in PEF values compared with salbutamol tablets when both treatment periods were considered, and patients considered they obtained longer lasting relief with the aminophylline preparation.