The synthesis of pyrido[4,3-d]pyrimidin-4(3H)-ones from 4-amino-nicotinic acid
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 2613-2617
- https://doi.org/10.1039/j39670002613
Abstract
Treatment of either a pyrido[4,3-d][1,3]oxazin-4-one or an ethyl 4-amidonicotinate with amines yields a 4-amidonicotinamide which may be cyclised by longer contact with the amine, or by heat, to give a pyrido[4,3-d]-pyrimidin-4(3H)-one. Some typical infrared and nuclear magnetic resonance spectra are discussed.Keywords
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