Distribution of CO and Radiochromium in Blood and Tissues of Rabbit and Dog. II. Radiochromium.

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Abstract
Carbon monoxide and autogenous red cells labeled with Cr51 were administered simultaneously to dogs and rabbits. Tissue homogenates and blood were then analyzed for radioactivity and CO content. Small amounts of Cr51 accumulated regularly in spleen and lung and, when the cells were delivered via the portal vein, in the liver. No sequestration occurred in brain, kidneys or extremities. Prolonged storage of tagged cells, particularly when suspended in saline rather than plasma, increased the loss of Cr51 from the cells in vitro and by early sequestration after injection of the cells into their donors. When cells were stored in saline for only 1 day, combined losses caused by sequestration and by in vitro leakage were too small to influence the results of blood volume determinations.