NOCTURNAL AND INSULIN GASTRIC SECRETION

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Abstract
This study on normal inmates and inmates with duodenal ulcer in a penitentiary was undertaken to settle the question of whether an ulcer patient secretes more gastric juice than a normal person. Previous studies by other investigators have demonstrated that most duodenal ulcer patients secrete a higher nocturnal volume of gastric juice with a higher acidity than normal persons. Chalfen, in 1928, reported that normal subjects do not secrete acid during the night, in contradistinction to high acid secretion in ulcer patients. Winkelstein, in 1935, confirmed these findings; 45% of his normal subjects did not reveal any free hydrochloric acid. On the other hand, Sandweiss and associates,1 in 1946, and Brown and co-workers,2 in 1952, found no significant difference between the nocturnal secretion of normal persons and ulcer patients, when no retention was present in the latter group. A historical review of the literature on gastric secretion in