Effects of Ouabain on the Anticellular and Antiviral Activities of Human and Mouse Interferon
- 1 March 1977
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 34 (3) , 537-540
- https://doi.org/10.1099/0022-1317-34-3-537
Abstract
When transformed human embryonic cells RSa and RSb were treated for 48 h with 10-7 M-ouabain and 1000 units/ml of human leukocyte interferon, there was an additive suppression of cell growth. In contrast, the antiviral [vs. vesicular stomatitis virus] action of the human interferon was inhibited by this concentration of ouabain. Similar effects of combined treatment with interferon and ouabain were found with IFr [RSa derived] cells (which are relatively resistant to the anticellular effect of interferon), and with mouse K3b cells.This publication has 3 references indexed in Scilit:
- Effects of Interferon on Cell and Virus Growth in Transformed Human Cell LinesJournal of General Virology, 1976
- Effects of Interferon on the Human Clonal Cell Line, RSa: Inhibition of Macromolecular SynthesisJournal of General Virology, 1976
- Regulation of cellular growth by sodium pump activityJournal of Cellular Physiology, 1976