STUDIES OF THE BIOLOGICAL ACTION OF SERUM GONADOTROPHIN

Publisher Website
Google Scholar
Abstract
Interpretation of the ovarian response to the gonadotrophin from pregnant mares' serum (serum gonadotrophin) in the intact immature rat is complicated by the secretion of endogenous gonadotrophin from the rat's own pituitary. The difficulty can be overcome by using hypophysectomized rats, but this procedure has its own disadvantages. The injection should not be given until sufficient time has elapsed after the operation to allow any circulating gonadotrophin to be destroyed. For this reason authors who normally use hypophysectomized rats give their initial gonadotrophin injection 5–12 days after hypophysectomy. At this time, however, the ovaries are atrophic and there is evidence that they are then relatively unresponsive to gonadotrophic stimulation [Williams, 1940]. I am not aware of any published experiments to determine the actual time after hypophysectomy at which a basal state of ovarian responsiveness is attained. This has been the main object of the experiment reported here. METHOD Immature female

This publication has 0 references indexed in Scilit: