Immunohistochemical demonstration of thyroid hormone in paraffin embedded human thyroid tissues.

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Abstract
The immunoperoxidase technique was applicable to localization of thyroxine (T4) and triiodothyronine (T3) in 10% formalin-fixed paraffin sections of human thyroid tissues including tumors. T4 was demonstrated in the colloid substance and on the luminal surface of the follicular epithelia, and less frequently in the cytoplasm of the non-neoplastic epithelia. Cytoplasmic staining of T4 was remarkable in some thyroid tumors. T3 localization was observed rather in the cytoplasm of the epithelial cells than in the colloid substance. Most thyroid neoplasms, which were clinically diagnosed as nonfunctioning, showed more or less positive staining for either T4 or T3.

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