Isolation of Auxotrophs of Penicillium chrysogenum and their Penicillin Yields

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Abstract
As a pre-liminary to an investigation of the inheritance of penicillin productivity in Penicillium chrysogenum several strains were genetically labelled with nutritional deficiencies and mutant spore colors. Few auxotrophs of P. chrysogenum retained the potential for penicillin yield of their parents. An analysis suggests that when loss of penicillin production occurred in an auxotroph it was most likely due to pleiotropic effects of the single mutation to auxotrophy.