Structure-Function and Pathogenesis Studies of Streptococcus pyogenes Extracellular Cysteine Protease
- 1 January 1997
- book chapter
- Published by Springer Nature
- Vol. 418, 589-592
- https://doi.org/10.1007/978-1-4899-1825-3_136
Abstract
Replacement of the single cysteine residue (C192) with serine in the Streptococcus pyogenes extracellular cysteine protease (SCP) prevented auto-catalytic processing of the 40-kDa zymogen to the 28-kDa mature form and eliminated proteolytic activity. SCP incubated with human endothelial cells induced a time- and concentration-dependent increase in a 66-kDa gelatinase/type IV collagenase in culture supernatants. Activation of this gelatinase/collagenase may contribute to endothelial cell damage, tissue destruction, and hemodynamic derangement observed in some patients with severe, invasive S. pyogenes infection.Keywords
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