Mucosal gastrin receptor. III. Regulation by gastrin

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Abstract
Specific binding of 125I-labeled gastrin to rat gastric mucosal membranes varied with serum gastrin levels. The dissociation equilibrium constants were not significantly different between receptor preparations. The binding capacities of the membrane preparations were directly correlated with serum gastrin levels. Fasting, feeding a liquid diet and antrectomy significantly decreased serum gastrin and the concentrations of the gastrin receptor. Treatment of fasted and liquid-fed animals with pentagastrin prevented the decrease in receptors. Vagotomy increased binding capacity and serum gastrin levels. Apparently gastrin stimulates the production of its own receptor. The upregulation of the gastrin receptor was evident if the binding capacity was expressed per mg of protein, per .mu.g of DNA or per amount of 125I-labeled choleragen bound to the same membrane preparation. Apparently biological response to gastrin is controlled in part by the regulation of the number of gastrin receptors present. Gastrin evidently plays a role in this regulatory process.

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