ASSESSMENT OF PANCREATIC DUCTAL PENETRATION OF ANTIBIOTICS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 50  (12) , 666-667
Abstract
Pancreatic ductal penetration of antibiotics in not uniform. Antibiotic therapy for pancreatic and pancreatic-related infections, theoretically, is enhanced by drugs that reach the ductal system. The pancreatic ductal penetrance of Cefamandole (1 g), Amikacin (7.5 mg/kg) and Chloramphenicol (1 g) given as a single i.v. dose prior to endoscopic retrograde cholangiopancreatography was studied in 10 patients. Serum and pancreatic juice were collected simultaneously, frozen and later assayed for antibiotic concentration. Each antibiotic achieved its expected therapeutic serum level. In contrast, pancreatic ductal levels of Cefamandol and Amikacin were subtherapeutic. Chloramphenicol levels were therapeutic. Further studies are needed to identify other antibiotics with good pancreatic ductal penetrance.