Human Fatty Marrow Aromatizes Androgen to Estrogen
- 1 August 1980
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 51 (2) , 394-396
- https://doi.org/10.1210/jcem-51-2-394
Abstract
Human female fatty marrow from the femur and iliac crest has the ability to convert androgen to estrogen. Homogenates of fatty marrow incubated with 19–[6,7–3H]hydroxyandrostenedione (19-hydroxyandrost-4-ene-3,17-dione) and an NADPH-generating system produced estrogen in all six samples. The major estrogen produced in five of the cases was [3H]estrone, the immediate product of the aromatization of 19-hydroxyandrostenedione. One case produced [3H]estradiol. The local formation of estrogens in bone marrow may be important to the closure of the epiphyses at puberty and may affect osteoporosis at the menopause.This publication has 1 reference indexed in Scilit:
- Osteoporosis and the Replacement of Cell Populations of the Marrow by Adipose TissueClinical Orthopaedics and Related Research, 1971