An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus).
- 1 September 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (9) , 3744-3747
- https://doi.org/10.1073/pnas.72.9.3744
Abstract
Castration of mice in freerunning conditions (total darkness, DD) causes a reduction of running wheel activity in the beginning of the active period (alpha) and stimulates activity at the end of alpha. Simultaneously, the period (tau) of the freerunning rhythm is increased. Both effects are abolished by implantation of a Silastic capsule from which a physiological dose of testosterone is released at a constant rate. The results are tentatively explained by differential endocrine influences on two oscillating components in the pacemaker of the circadian activity rhythm.Keywords
This publication has 6 references indexed in Scilit:
- Biological Rhythms and Animal BehaviorAnnual Review of Psychology, 1975
- Testosterone Induces "Splitting" of Circadian Locomotor Activity Rhythms in BirdsScience, 1974
- A retinohypothalamic projection in the ratJournal of Comparative Neurology, 1972
- Circadian rhythms in adrenal organ cultures.1971
- Persistence of Diurnal Periodicity of CRF Activity in Adrenalectomized and Hypophysectomized RatsEndocrinologia Japonica, 1971
- Sustained release hormonal preparations. I. Diffusion of various steroids through polymer membranesSteroids, 1968