EVALUATION OF BACTERIAL ATTACHMENT TO ACID-TREATED BLADDER EPITHELIUM

  • 1 January 1982
    • journal article
    • research article
    • p. 825-830
Abstract
Rapid (60 s) acid treamtent of intact rat bladders was used to evaluate bacterial interactions with bladder mucin and mucosal cells. Using the rat model system, scanning electron microscopy indicated that short term acid treatment removed the mucin layer, but also modified the bladder epithelial cell surface. Although the treatment which removed mucin allowed an increase in random bacterial attachment, the increase could also be attributable to acid modification of the mucosa. Examination of the acid treated rabbit bladders also showed mucin removal and simultaneously bladder epithelium modification. Thus, short term acid treatment removes mucin, modifies the epithelial layer and appears to nonspecifically increse bacterial attachment on the mucosa by modifying the mucosal surface.

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