ONE STEP RESISTANCE DEVELOPMENT TO ISONIAZID AND SODIUM- p -AMINOSALICYLATE
- 1 October 1953
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 66 (4) , 468-469
- https://doi.org/10.1128/jb.66.4.468-469.1953
Abstract
The mutation rate per bacterium per generation of Bacillus megatherium to isonicotinylhydrazine resistance is 6([plus or minus] 1.5) x 10-5. The rate to Na-p-aminosalicylate resistance is 1([plus or minus] 0.3) x 10-6. The rate of mutation to double resistance is 8([plus or minus] 1.8) x 10-10, i.e., 7-8 times higher than the theoretically expected value derived as the product of the individual mutation rates. The significance of these observations is discussed.Keywords
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- The Occurrence of Tubercle Bacilli Resistant to P-aminosalicylic Acid (PAS)Diseases of the Chest, 1949
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