EFFECTS OF SODIUM LACTATE ON OXYGEN TOXICITY IN THE RAT*

1 March 1965

journal article
research article
Published by Wiley in Annals of the New York Academy of Sciences

Vol. 121 (3) , 829-835
https://doi.org/10.1111/j.1749-6632.1965.tb14252.x

Abstract

Summary: Sodium lactate increases survival when administered daily to rats exposed to 98 per cent oxygen. It is suggested that the mechanism of lactate protection may be related to alterations in the redox state of pyridine nucleotides.

Keywords

This publication has 16 references indexed in Scilit:

Sodium Bicarbonate: Increase in Survival Rate of Rats Inhaling Oxygen
Science, 1963
Intracellular Oxidation-Reduction States in Vivo
Science, 1962
Lactate versus bicarbonate: A reconsideration of the therapy of metabolic acidosis
The American Journal of Medicine, 1962
PULMONARY DAMAGE DUE TO HIGH PRESSURE OXYGEN BREATHING IN RATS
Immunology & Cell Biology, 1962
A New Type of Autoxidation Reaction: Cause of the Instability of Cytochrome c Reductase
Nature, 1960
Role of Adrenalectomy and Adrenal-Cortical Hormones in Oxygen Poisoning
American Journal of Physiology-Legacy Content, 1954
Blood and Tissue Gases of Animals Exposed to One and Seven Atmospheres of Oxygen or Air
American Journal of Physiology-Legacy Content, 1953
The effect of breathing oxygen at atmospheric pressure on tissue oxygen and carbon dioxide tensions
The Journal of Physiology, 1949
The toxic effects of oxygen on brain metabolism and on tissue enzymes
Biochemical Journal, 1946