Characterization of seven new monoclonal antibodies against human DR, DR + DP and DQ1 + DQ3 antigens
- 1 November 1986
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 28 (5) , 288-291
- https://doi.org/10.1111/j.1399-0039.1986.tb00498.x
Abstract
Seven murine monoclonal antibodies were prepared that react with human class II antigens. Four of them (HL-39, MEM-12, MEM-24G, and MEM-32B: react with a monomorphic determinant dependent on association of heavy and light chains of DR antigens, two others (HL-38 and HL-40) recognize a monomorphic determinant localized on the light chains of DR and DP antigens. The antibody HL-37 is directed against a determinant present on DQ1 and DQ3, but not DQ2 molecules; at least in the case of DQ1, the epitope recognized is located on the light chain.Keywords
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