Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes
- 1 January 1989
- Vol. 2 (1) , 67-69
- https://doi.org/10.1002/glia.440020108
Abstract
Addition of quisqualate (a heterocyclic analogue of glutamate) reduced [methyl‐3H]thymidine incorporation and cell proliferation in primary cultures of rat cortical astrocytes. The inhibitory action of quisqualate was mimicked by glutamate and ibotenate, whereas kainate, N‐methyl‐D‐aspartate (NMDA) and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate (AMPA) were inactive. These results suggest that activation of a specific class of excitatory amino acid receptors contributes to the regulation of growth and proliferation of glial cells in primary culture.Keywords
This publication has 6 references indexed in Scilit:
- Effect of epidermal growth factor and insulin on DNA, RNA, and cytoskeletal protein labeling in primary rat astroglial cell culturesJournal of Neuroscience Research, 1988
- Glutamate opens Na+/K+ channels in cultured astrocytesGlia, 1988
- Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium fluxNeuroscience Letters, 1986
- The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cellsJournal of Neuroscience, 1986
- Pharmacological properties of gamma-aminobutyric acid-, glutamate-, and aspartate-induced depolarizations in cultured astrocytesJournal of Neuroscience, 1985
- UPTAKE AND METABOLISM OF GLUTAMATE IN ASTROCYTES CULTURED FROM DISSOCIATED MOUSE BRAIN HEMISPHERESJournal of Neurochemistry, 1977