Pernicious Anemia

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Abstract
Pernicious anemia is the most common cause of vitamin B12 deficiency. Vitamin B12 deficiency has many causes; the term “pernicious anemia” applies only to the condition associated with chronic atrophic gastritis. A recent population survey revealed that 1.9 percent of persons more than 60 years old have undiagnosed pernicious anemia.1 Earlier studies suggested that pernicious anemia is restricted to Northern Europeans.2 However, subsequent studies have reported the disease in black and Latin-American subjects, with an earlier age of onset in black women.1,3 Although the disease is silent until the end stage, the underlying gastric lesion can be . . .