Triplex DNA and human disease
- 1 January 2007
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 12 (8-12) , 4536-46
- https://doi.org/10.2741/2408
Abstract
Mutagenesis is the fulcrum for the balance between the fidelity of the genetic code and evolution. While there are an enormous number of extrinsic factors driving mutagenesis, alternative DNA secondary structure is one of the intrinsic components that impacts regional genomic stability. Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine polypyrimidine mirror repeat sequences.Keywords
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