Effect of an acute dose of ethanol on the hepatotoxicity due to carbon tetrachloride

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Abstract
ABSTRACT— To study the effect of an acute dose of alcohol on the hepatotoxicity due to CCl4, rats received alcohol (4 g/kg BW) and/or CCl4 (1.5 ml/kg BW) by concomitant intragastric intubation. Compared to animals receiving CCl4 alone, the simultaneous application of CCl4 and alcohol resulted 12 h after administration in significantly lower serum activities of glutamate oxalacetate transaminase (1005±70 vs 739±47; p4 and ethanol, compared to CCl4 alone, whereas the reversed constellation could be demonstrated 36 h after administration. These results therefore show that in the early phase of CCl4 intoxication an acute dose of alcohol may partially protect from CCl4 hepatotoxicity, whereas potentiation was observed under these experimental conditions in the late phase of CCl4 intoxication.

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