Intestinal perfusion of dietary levels of aluminium: association with the mucosa.
Open Access
- 1 August 1994
- Vol. 35 (8) , 1053-1057
- https://doi.org/10.1136/gut.35.8.1053
Abstract
An aluminium (93 microM) sulphate solution freshly adjusted to pH 7.0 was perfused through the rat small bowel to mimic the reported physiological conditions that follow dietary aluminium ingestion. One third of this aluminium was taken up from the perfusate, but > 90% of this was then recovered from the intestinal mucus/mucosa and most (> 70%) from the distal third of the small bowel. The fresh perfusate was shown by ultrafiltration to contain largely particulate/colloidal aluminium-hydroxide, and this probably adhered to intestinal mucus which may be an important barrier to the gastrointestinal absorption of aluminium.Keywords
This publication has 22 references indexed in Scilit:
- Absorbed aluminium is found with two cytosolic protein fractions, other than ferritin, in the rat duodenum.Gut, 1993
- The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorptionProceedings of the Nutrition Society, 1993
- Intestinal translocation of particulates — implications for drug and antigen deliveryAdvanced Drug Delivery Reviews, 1990
- Aluminium deposition in bone after contamination of drinking water supplyThe Lancet, 1990
- Intestinal absorption of aluminum in rats: Stimulation by citric acid and inhibition by dinitrophenolToxicology and Applied Pharmacology, 1989
- Influence of renal impairment, chemical form, and serum protein binding on intravenous and oral aluminum kinetics in the rabbitToxicology and Applied Pharmacology, 1988
- The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats*1Toxicology and Applied Pharmacology, 1987
- Metal Absorption and the Intestinal Mucus LayerDigestion, 1987
- Metabolism and possible health effects of aluminum.Environmental Health Perspectives, 1986
- Counter-ion binding to mucus glycoproteinsJournal of Pharmacy and Pharmacology, 1984