Selective effects of somatostatin-14, -25 and -28 on in vitro insulin and glucagon secretion
- 1 May 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 291 (5810) , 76-77
- https://doi.org/10.1038/291076a0
Abstract
SRIF-28 [somatostatin-28 from porcine gut] and SRIF-25 [somatostatin-25 from ovine hypothalamus] are more potent than SRIF-14 [somatostatin-14] in the inhibition of insulin release, but SRIF-14 preferentially inhibits glucagon release. SRIF-28 and SRIF-25 are probably not mere biosynthetic precursors of SRIF-14 and their differential release may be physiologically important.Keywords
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