Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)
- 1 February 1978
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 80 (2) , 243-248
- https://doi.org/10.1017/s0022172400053596
Abstract
SUMMARY: Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong/8/73. Preliminary experiments showed that the 30c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the ‘current’ 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but the vaccine prepared from the current strain gave more.Keywords
This publication has 14 references indexed in Scilit:
- Isolation of anti-haemagglutinin antibodies with an influenza a virus immunoadsorbentJournal of Immunological Methods, 1976
- RECOMBINANT WRL 105 STRAIN LIVE ATTENUATED INFLUENZA VACCINE: Immunogenicity, Reactivity, and TransmissibilityThe Lancet, 1975
- ANTIBODY RESPONSES TO ANTIGENIC DETERMINANTS OF INFLUENZA VIRUS HEMAGGLUTININThe Journal of Experimental Medicine, 1974
- Studies on antigenic variation in influenza virus. Evidence for multiple antigenic determinants on the hemagglutinin subunits of A/Hong Kong/68 (H3 N2) virus and the A/England/72 strainsVirology, 1974
- Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic 'drift' for the Hong Kong virus.1974
- Efficacy of “Hong Kong” Vaccine in Preventing “England” Variant Influenza a in 1972New England Journal of Medicine, 1973
- CONTROLLED TRIAL OF INACTIVATED INFLUENZA VACCINE CONTAINING THE A/HONG KONG STRAIN DURING AN OUTBREAK OF INFLUENZA DUE TO THE A/ENGLAND/42/72 STRAINThe Lancet, 1973
- [Selection of dominant mutants of the influenza A (Hong Kong) virus by immunological pressure].1973
- Influenzavirus neuraminidase and neuraminidase-inhibition test procedures.1973
- The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B virusesEpidemiology and Infection, 1972