Yellow Fever Virus NS2B–NS3 Protease: Charged-to-Alanine Mutagenesis and Deletion Analysis Define Regions Important for Protease Complex Formation and Function

This publication has 49 references indexed in Scilit:

• Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.
  Journal of General Virology, 1999
• Cotranslational Membrane Insertion of the Serine Proteinase Precursor NS2B-NS3(Pro) of Dengue Virus Type 2 Is Required for Efficient in Vitro Processing and Is Mediated through the Hydrophobic Regions of NS2B
  Journal of Biological Chemistry, 1997
• Enhancement of Hepatitis C Virus NS3 Proteinase Activity by Association with NS4A-Specific Synthetic Peptides: Identification of Sequence and Critical Residues of NS4A for the Cofactor Activity
  Virology, 1996
• Dengue 2 Virus NS2B and NS3 Form a Stable Complex That Can Cleave NS3 within the Helicase Domain
  Virology, 1993
• Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease
  Journal of Virology, 1992
• Identification of functional residues in proteins by charged-to-alanine scanning mutagenesis
  Methods, 1991
• Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
  Proceedings of the National Academy of Sciences, 1990
• Production of yellow fever virus proteins in infected cells: Identification of discrete polyprotein species and analysis of cleavage kinetics using region-specific polyclonal antisera
  Virology, 1990
• Detection of a trypsin-like serine protease domain in flaviviruses and pestviruses
  Virology, 1989
• N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases
  Nucleic Acids Research, 1989