Successful treatment of HTLV‐1‐associated acute adult T‐cell leukaemia lymphoma by allogeneic bone marrow transplantation
- 1 September 1996
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 94 (4) , 713-715
- https://doi.org/10.1046/j.1365-2141.1996.02338.x
Abstract
HTLV-1-associated acute adult T-cell leukaemia-lymphoma (ATL) is a highly aggressive malignant disorder with a median survival of 6 months or less. We describe an Afro-Caribbean female with very poor prognosis ATL who underwent chemotherapy with a 4 d infusion schedule of cyclophosphamide, doxorubicin and etoposide, followed by successful allogeneic bone marrow transplantation (BMT) from her HTLV-1-negative histocompatibile sister. The patient remains in complete remission 23 months after BMT and has 100% donor haemopoiesis with no evidence of HTLV-1 infection on PCR testing. We suggest that allo-BMT can prolong disease-free survival or may even be curative in HTLV patients.Keywords
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