Activities of Polymyxin B and Cecropin A-Melittin Peptide CA(1-8)M(1-18) against a Multiresistant Strain of Acinetobacter baumannii
Open Access
- 1 March 2002
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (3) , 875-878
- https://doi.org/10.1128/aac.46.3.875-878.2002
Abstract
Polymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTGLPALIS-NH 2 ) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against Acinetobacter .Keywords
This publication has 20 references indexed in Scilit:
- Interaction of Cationic Antimicrobial Peptides with Model MembranesJournal of Biological Chemistry, 2001
- Stages of Polymyxin B Interaction with the Escherichia coli Cell EnvelopeAntimicrobial Agents and Chemotherapy, 2000
- Mechanism of Interaction of Different Classes of Cationic Antimicrobial Peptides with Planar Bilayers and with the Cytoplasmic Membrane ofEscherichia coliBiochemistry, 1999
- Ability of cecropin B to penetrate the enterobacterial outer membraneAntimicrobial Agents and Chemotherapy, 1994
- Improvement of outer membrane-permeabilizing and lipopolysaccharide-binding activities of an antimicrobial cationic peptide by C-terminal modificationAntimicrobial Agents and Chemotherapy, 1994
- The interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane of Pseudomonas aeruginosaMolecular Microbiology, 1994
- All-D amino acid-containing channel-forming antibiotic peptides.Proceedings of the National Academy of Sciences, 1990
- Antibacterial and antimalarial properties of peptides that are cecropin‐melittin hybridsFEBS Letters, 1989
- Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxinAntimicrobial Agents and Chemotherapy, 1986
- Inhibition of Escherichia coli growth and respiration by polymyxin B covalently attached to agarose beadsBiochemistry, 1977