Diet-Induced Changes in Glucose and Triglycerides Are Associated with Changes in Plasminogen Activator Inhibitor Levels
- 1 January 1991
- journal article
- clinical trial
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 21 (3) , 175-180
- https://doi.org/10.1159/000216223
Abstract
Twenty-four healthy female subjects volunteered to participate in an experiment in which they maintained a high-fat/low-carbohydrate (CHO) diet followed by a low-fat/high-CHO diet or vice versa in a cross-over study design. In bivariate correlation analysis, only glucose (r = 0.52, p < 0.05) and triglycerides (r = 0.53, p < 0.05) correlated with changes in plasminogen activator inhibitor type 1 (PAI-1) activity. A second-degree polynomial response surface model suggested that transition from a high-fat/low-CHO diet to a low-fat/high-CHO diet is associated with reduced levels of PAI-1 provided that glucose and triglyceride levels are not elevated by more than 1.2 and 0.5 mmol/l, respectively.Keywords
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