THE SIGNIFICANCE OF HUMAN BLOOD TRYPSIN; DIRECT DETERMINATION OF THROMBIN AND PLASMIN IN HUMAN PLASMA

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Abstract
The previously described method for human plasmin determination has been simplified and applied directly to plasma. A virtually identical method for the direct determination of human thrombin in plasma is also presented. Both procedures are quantitative and clinically feasible. The existence in plasma of a non-clotting, only slightly fibrinolytic, active tryptic enzyme, Human Blood Trypsin, is firmly established by the data. The suggestion is made that human blood trypsin may be the activator in the proenzyme to enzyme conversion system for both plasmin and thrombin. Further, both enzymes may arise from different derivatives of a common precursor protein.

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