SIGNIFICANCE OF SIMULTANEOUS DETERMINATION OF CARBAMAZEPINE AND ITS 10,11-EPOXIDE FROM PLASMA AND HUMAN ERYTHROCYTES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (5) , 222-226
Abstract
The distribution of carbamazepine and its 10,11-epoxide derivative into human erythrocytes was studied in child and adult epileptics on long-term therapy. Carbamazepine penetrated into erythrocytes, where the mean concentration of the drug was in rational agreement with the unbound fraction in plasma. The relationship between the percentage of carbamazepine concentration in red cell and the drug level in plasma resembled the relationship between the percentage of unbound carbamazepine and the drug level in plasma. This relationship was described in the literature recently. By determining the ratio of carbamazepine in red cells to the drug in plasma, the unbound fraction can probably be deduced. Carbamazepine-10,11-epoxide was not found in red cells.

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