Mutations in the Retinoblastoma-related Gene RB2 / p130 in Adult T-cell Leukaemia/Lymphoma
- 1 January 2003
- journal article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 44 (4) , 699-701
- https://doi.org/10.1080/1042819031000063480
Abstract
The retinoblastoma (Rb) family consists of the tumor suppressor Rb/p105 and related proteins p107 and Rb2/p130. Although the involvement of the RB/p105 gene in Adult T-cell leukaemia/lymphoma (ATL) has been studied, no mutational data is reported regarding the RB2/p130 gene in ATL. We screened for mutations of the RB2/p130 gene. Mutation was detected in 1 of 41 primary ATL sample. This is the first report describing mutation of the RB2/p130 gene in ATL, suggesting that RB2/p130 may be involved in the development of ATL, and may behave as a tumor suppressor gene in T lymphocytes.Keywords
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