Abstract
Influenza is a disease known since antiquity that continues to afflict large numbers of people and cause many deaths throughout the world. The annual epidemic and the continued threat of a pandemic constitute a major infectious-disease problem.18 Although the prevention of the spread of virus by ill persons and the removal of virus in transit in the environment could theoretically contribute to the control of influenza, effective control requires the optimal use of vaccines and antiviral drugs. At present, a vaccine and four antiviral drugs are approved in the United States and many other countries for the prevention and . . .