EFFECT OF NITROSOUREA DERIVATIVE RPCNU (ICIG 1163) ON DEVELOPMENT OF FRIEND LEUKEMIA IN MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 26  (3) , 176-181
Abstract
Friend leukemia was used as an experimental model to study the action of a ribofuranosyl derivative of nitrosourea:RPCNU. This new product was known to be active in L1210 leukemia and immunosuppressive. RPCNU significantly decreases the splenomegaly induced in DBA2 mice by Friend virus when it is given at a time ranging from 7 days before to 14 days after virus inoculation. The survival time in treated leukemic groups is also greatly increased. Viral content of spleen extracts of treated leukemic mice is not reduced. RPCNU cannot be considered as an antiviral agent. A comparison between survival of leukemic and nonleukemic mice treated with different doses showed that the effectiveness of RPCNU is correlated with its toxicity. The effect of RPCNU on Friend leukemia by cytotoxicity on hematopoietic stem cells is discussed in this paper.

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