Action of Newcastle Disease Virus on Human Blood Platelets

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Abstract
Newcastle Disease Virus induces a viscous metamorphosis like process in washed platelets. This virus liberates from platelets lactic dehydrogenase and pyruvate kinase, depletes their ATP content and impairs their ability to concentrate 5-hydroxy-tryptamine. Since Newcastle Disease Virus has adenosine triphosphatase activity, a possible role of this viral enzyme in the production of viscous metamorphosis and in inhibition of clot retraction is discussed. Treatment of platelets by Newcastle Disease Virus or by particulate fraction from normal allantoic fluid causes liberation of a platelet factor 3-like substance. * This study was supported by grant AI-04211 from the National Institute of Health, USA.