Evaluation of the Accuracy of Radionuclide Measurement of Regional Pulmonary Perfusion

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Abstract
This study examines (he accuracy of radionuclide methods currently used for assessing regional pulmonary function in patients. Dogs were heparinized, exsanguinated, and their lungs excised. Lung preparations with each main stem bronchus and main pulmonary artery individually cannulated were positioned over a matrix of 291 scintillation detectors. Separate respirators permitted ventilation of each lung at selected rates and volumes. Blood passed from a reservoir through a common mixing chamber for injection and was forced at varying rates into the lungs by two fixed volume roller pumps. Simultaneous counts in each square centimeter over the lung were recorded on computer tape during radionuclide administration. Pulmonary perfusion determinations using both MAA I131 and 133xenon saline correlated well with the known distribution of blood flow (S.E. 2.54 and 1.33). Greatly uneven ventilation to each lung of a preparation caused a small decrease in the accuracy of 133Xe saline perfusion measurements. It is concluded that properly applied radionuclide measurements accurately quantitate regional pulmonary perfusion.

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