Idiotypic relationship of anti‐Ia.2 antibodies

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Abstract
Alloantiserum and hybridoma‐derived anti‐Ia antibodies were investigated for their idiotypic similarity using 4 monoclonal anti‐idiotypes raised against monoclonal anti‐Ia. With one anti‐idiotype, idiotypic cross‐reactivity could be found between three independently derived monoclonal BALB/c anti‐Ia antibodies, all of which were directed against the same serological determinant, Ia.2. The respective idiotype, tentatively designated la.2 idiotope, could also be demonstrated on anti‐Ia.2 antibodies in BALB/c alloantisera, but not on anti‐Ia against other specificities. The expression of the Ia.2 idiotope is linked to the Igh allotype; the use of Ig‐recombinant mice allowed us to map the Igh‐Ia.2 locus to the left of the T1S marker in the Igha V region.
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