Intrinsic mechanisms controlling the mammalian gastro-oesophageal sphincter deprived of extrinsic nerve supply
Open Access
- 1 November 1968
- Vol. 23 (6) , 634-639
- https://doi.org/10.1136/thx.23.6.634
Abstract
The oesophagus and gastro-oesophageal junction of 13 guinea-pigs and 14 3-week-old kittens were removed and placed in oxygenated Tyrode's solution at 36 to 37° C. Sphincteric pressures were recorded before and after oesophageal distension. In these preparations changes in the tone of the gastro-oesophageal sphincter were observed in response to lower oesophageal distension. The sphincter of the guinea-pig responded by relaxation, whereas the sphincter of the kitten responded more often by contraction. The relaxation/contraction responses of the sphincter to oesophageal distension were independent of any extrinsic nerve supply and could be abolished by removal of a circular cuff of oesophageal muscle between the source of the stimulus and the gastro-oesophageal sphincter. The intramural mechanisms affecting gastro-oesophageal sphincteric tone probably are present in all mammals, including man.Keywords
This publication has 17 references indexed in Scilit:
- A NOTE ON THE COMPARATIVE ANATOMY OF THE CARDIO-OESOPHAGEAL JUNCTIONCells Tissues Organs, 1958
- COMPARISON OF CARDIAC AND PYLORIC SPHINCTERSThe Lancet, 1957
- The Gastroesophageal Sphincter in Healthy Human BeingsDigestion, 1956
- Quantitative Determination of HistaminePublished by Wiley ,1956
- The effects of vagotomy and phrenicotomy on the cardiaDigestive Diseases and Sciences, 1951
- A Miniature Pressure-recording DeviceScience, 1950
- LXXIII Observations on the Esophagus following VagotomyAnnals of Otology, Rhinology & Laryngology, 1950
- Attempt to Produce Experimental Cardiospasm in Dogs.Experimental Biology and Medicine, 1940
- The relation of the extrinsic nerves to the functional activity of the ŒsophagusBritish Journal of Surgery, 1934
- Studies on the innervation of smooth muscleThe Journal of Physiology, 1925