Chimeric SHIV that causes CD4+ T cell loss and AIDS in rhesus macaques
- 6 April 1998
- journal article
- Published by Wiley in Journal of Medical Primatology
- Vol. 27 (2-3) , 59-64
- https://doi.org/10.1111/j.1600-0684.1998.tb00227.x
Abstract
By animal to animal passage in rhesus and pig‐tailed macaques, we developed a rhesus model of HIV‐1 disease in humans. Rhesus macaques infected with a cell‐free stock of SHIVKU‐2 developed CD4+ T cell loss, primary lentiviral encephalitis and pneumonia, and AIDS. Six of nine rhesus macaques died within eight months post‐inoculation, while the remaining three are at five, five, and eight months post‐inoculation, respectively. Animals infected by either mucosal or parenteral routes of infection had a similar course of infection.Keywords
This publication has 12 references indexed in Scilit:
- Neuropathogenesis of Chimeric Simian/Human Immunodeficiency Virus infection In Pig‐tailed and Rhesus MacaquesBrain Pathology, 1997
- Characterization of the Pathogenic KU-SHIV Model of Acquired Immunodeficiency Syndrome in MacaquesAIDS Research and Human Retroviruses, 1997
- A Cell-Free Stock of Simian–Human Immunodeficiency Virus That Causes AIDS in Pig-Tailed Macaques Has a Limited Number of Amino Acid Substitutions in Both SIVmacand HIV-1 Regions of the Genome and Has Altered CytotropismVirology, 1997
- Animal model of mucosally transmitted human immunodeficiency virus type 1 disease: intravaginal and oral deposition of simian/human immunodeficiency virus in macaques results in systemic infection, elimination of CD4+ T cells, and AIDSJournal of Virology, 1997
- Initial characterization of viral sequences from a SHIV‐inoculated pig‐tailed macaque that developed AIDSJournal of Medical Primatology, 1996
- Intracerebral infusion of TNF-α and IL-6 failed to activate latent SIV infection in the brains of macaques inoculated with macrophage-tropic neuroadapted SIVmacJournal of Leukocyte Biology, 1994
- Pathogenesis of SIVmac Infection in Chinese and Indian Rhesus Macaques: Effects of Splenectomy on Virus BurdenVirology, 1994