Oleic acid transfer from microsomes to egg lecithin liposomes: Participation of fatty acid binding protein

Abstract
Oleic acid transfer from [rat liver] microsomes or mitochondria to egg lecithin liposomes was stimulated by fatty acid binding protein [FABP]. By gel filtration, it could be demonstrated that this protein incorporates oleic acid into liposomes. FABP transfer activity was higher using microsomes rather than mitochondria, which suggests a selective interaction with different kinds of membranes. Transfer of oleic acid by this soluble protein is greater than that of stearic acid. FABP may participate in the intracellular transport of fatty acids.