Potentiation of the cGMP-induced Guinea pig acrosome reaction by zinc
- 1 August 1980
- journal article
- research article
- Published by Wiley in Journal of Experimental Zoology
- Vol. 213 (2) , 289-291
- https://doi.org/10.1002/jez.1402130217
Abstract
The addition of 8 bromo cGMP (10 mM) immediately (∼2 min) upon suspension of Guinea pig sperm in glucose-free BWW medium induces a significant number of acrosome reactions within minutes. The simultaneous addition of micromolar concentrations of ZnCl2 (25–1000 μM) potentiates the cGMP effects. Mid-micromolar concentrations were able to dramatically increase the percentage of acrosome reactions by a factor of 6.5 over 8 bromo cGMP alone. The induction of acrosome reactions was dependent upon external Ca++, and it is suggested that in this species Zn++ flnctions by affecting cyclic nucleotide metabolism and/or Ca++ flux.This publication has 9 references indexed in Scilit:
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