Diphenylhydantoin Inhibition of Sodium Conductance in Squid Giant Axon
- 1 July 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (7) , 1758-1760
- https://doi.org/10.1073/pnas.69.7.1758
Abstract
Diphenylhydantoin, in concentration of 5-50 muM, decreases the early, transient (sodium) currents of voltage-clamped squid giant axons. These effects are dose-dependent and largely reversible. It appears that diphenylhydantoin reduces the number of open, early, transient (sodium) channels.Keywords
This publication has 13 references indexed in Scilit:
- Direct and Rapid Description of the Individual Ionic Currents of Squid Axon Membrane by Ramp Potential ControlBiophysical Journal, 1970
- Equilibrium and Kinetic Properties of the Interaction between Tetrodotoxin and the Excitable Membrane of the Squid Giant AxonThe Journal of general physiology, 1970
- Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic EffectsCirculation, 1968
- Saxitoxin and Tetrodotoxin: Comparison of Nerve Blocking MechanismScience, 1967
- Comparison of Tetrodotoxin and Procaine in Internally Perfused Squid Giant AxonsThe Journal of general physiology, 1967
- DRUG EFFECTS ON SPONTANEOUS ELECTRICAL ACTIVITY OF SQUID GIANT AXON1967
- Effect of procaine on electrical properties of squid axon membraneAmerican Journal of Physiology-Legacy Content, 1959
- A quantitative description of membrane current and its application to conduction and excitation in nerveThe Journal of Physiology, 1952
- Effect of Dilantin and Mesantoin on the Giant Axon of the Squid.Experimental Biology and Medicine, 1951
- The neuropharmacology of antiepileptics.1949