Favorable Interactions between Enfuvirtide and 1-β- d -2,6-Diaminopurine Dioxolane In Vitro
- 1 November 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (11) , 3644-6
- https://doi.org/10.1128/aac.47.11.3644-3646.2003
Abstract
We evaluated the in vitro anti-human immunodeficiency virus type 1 (HIV-1) interactions between 1- β- d -2,6-diaminopurine dioxolane (DAPD) and enfuvirtide (T-20) against clinical isolates sensitive and resistant to reverse transcriptase and protease inhibitors. Interactions between T-20 and DAPD were synergistic to nearly additive, with combination index values ranging from 0.53 to 1.06 at 95% inhibitory concentrations. These studies suggest that a combination of T-20 and DAPD might be useful in the treatment of antiretroviral drug-experienced patients.Keywords
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