Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Top Cited Papers
- 1 August 2000
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 3 (8) , 757-758
- https://doi.org/10.1038/77660
Abstract
Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.Keywords
This publication has 15 references indexed in Scilit:
- Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell LineJournal of Biological Chemistry, 2000
- Phosphoinositide 3-kinase: the key switch mechanism in insulin signallingBiochemical Journal, 1998
- Altered Cell Surface Expression and Signaling of Leptin Receptors Containing the fattyMutationPublished by Elsevier ,1998
- Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channelsNature, 1997
- Constitutive and impaired signaling of leptin receptors containing the Gln → Pro extracellular domain fatty mutationProceedings of the National Academy of Sciences, 1997
- Leptin Receptor of Zucker Fatty Rat Performs Reduced Signal TransductionDiabetes, 1997
- Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker RatsHormone and Metabolic Research, 1996
- Leptin receptor missense mutation in the fatty Zucker ratNature Genetics, 1996
- Tolbutamide excites rat glucoreceptive ventromedial hypothallamic neurones by indirect inhibition of ATP‐K+ channelsBritish Journal of Pharmacology, 1990
- Intraventricular insulin reduces food intake and body weight of lean but not obese zucker ratsAppetite, 1986