Treatment of Streptococcal Pharyngitis with Amoxicillin

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Abstract
Amoxicillin and penicillin V were used to treat pharyngeal infections due to group A β-hemolytic Streptococcus in children. Patients were assigned randomly to receive either antibiotic, both of which were administered in a dose of 125 mg three times a day for 10 days. Cultures were obtained from all patients before and three and five weeks after therapy. Cultures were T typed to distinguish recurrences from new infections. There were no differences in the two groups with respect to age, weight, physical findings, or laboratory data. Cure rates were 80.8 % for penicillin V and 76.6% for amoxicillin. These results were comparable to results of other therapeutic regimens. Approximately half the failures in each group were clinical recurrences. Amoxicillin was well tolerated, and fewer gastrointestinal side effects were seen with amoxicillin than with penicillin V. Five children treated with amoxicillin developed rashes similar to those seen with ampicillin. Amoxicillin was as effective as penicillin V in the treatment of pharyngitis due to group A Streptococcus.

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