Tumor Localization by Tumor Infiltrating Lymphocytes Labeled with Indium-111 in Patients With Metastatic Renal Cell Carcinoma, Melanoma, and Colorectal Cancer

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Abstract
Background Adoptive immunotherapy with autologous tumor infiltrating lymphocytes (TIL) is a promising approach for cancer biotherapy. One issue, however, is whether such cells actually migrate to sites of tumor after intravenous infusion. There have been several reports of tumor uptake of radiolabeled TIL in patients with metastatic melanoma, but efforts to visualize tumor with radiolabeled TIL in other tumor types reportedly have been unsuccessful. Methods Eight patients with metastatic cancer (5 renal, 2 melanoma, 1 colon) received an intravenous infusion of 2 to 100 billion autologous TIL, including 50 million TIL which had been conjugated to 500 μCi Indium-111, co-administered with interleukin-2 (IL-2). One patient received 1gm/m2 of cyclophosphamide one day prior to TIL; seven patients received interferon alpha2b for 4 days prior to receiving TIL. Total body gamma camera imaging, including single photon emission computerized tomography (SPECT), was performed at 24 and 48 hours. Results All eight pati...

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